An online gene activity database involved more than 45,000 mouse genes with ten different diseases may significantly reduce animal testing, demonstrated by a special study from the Francis Crick Institute. For instance, the allergy model contains over 100 genes and another module associated with T cells contains over 200 genes. researchers all over the world can learn interested gene activity such as in the lungs and blood of mice infected with a range of pathogens. It takes 10 years to build such an open access resource of gene expression that anyone in the world can use. the findings strongly suggest a role for targeting the online database as a novel potential alternative for data analyses instead of pooling the data from a large sample. According to the researchers.
The study have been published in Nature Communications.
Animal experiments Vs Data analysis database
Previously, researchers would have to create, infect, cull, obtain samples from mice and extract and sequence the RNA to study genes that they are interested in. Using a new app which the lab created for this study, researchers will be able to check the activity of any gene across a range of diseases without needing their own mice. This could prevent thousands of mice being used in individual experiments.
Introduction of the gene activity database
Using the new app, researchers anywhere in the world can look up gene activity in the lungs and blood of mice infected with a range of pathogens: the parasite Toxoplasma gondii, influenza virus and Respiratory Syncytial Virus (RSV), the bacterium Burkholderia pseudomallei, the fungus Candida albicans, or the allergen, house dust mite. They can also see gene activity in the blood of mice with listeria, murine cytomegalovirus, the malaria parasite Plasmodium chabaudi chabaudi, or a chronic Burkholderia pseudomallei infection.
Watch & Learn about the gene activity database
Original title：Gene activity database could spare thousands of mice